Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions

VL Villemagne; N Okamura

Journal article

Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions

VL Villemagne, N Okamura

Current Opinion in Neurobiology | Published : 2016

DOI: 10.1016/j.conb.2015.09.002

Abstract

In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. The cross-sectional and longitudinal assessment of the temporal and spatial patterns of tau deposition in the brain will allow a better understanding of the role tau plays in ageing as well as its relationship with cognition, genotype, and neurodegeneration. It is likely that selective tau imaging could be used as a diagnostic and prognostic bio..

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University of Melbourne Researchers

Victor Villemagne Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We thank Professors Christopher Rowe, Yukitsuda Kudo, Colin Masters, Kazuhiko Yanai, Shozo Furumoto, Drs Ryuichi Harada and Michelle Fodero-Tavoletti, and Louis F Destouches, Mrs Svetlana Pejoska-Bozinovski, Ms Fiona Lamb, and the Brain Research Institute for their assistance with this study. This review was supported in part by NHMRC Project Grant 1044361. VLV is supported by NHMRC Research Fellowship 1046471. The funding sources had no input into the design of this study, the analysis of data, or writing of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.